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Ev nova free registration code5/6/2023 Synthesis and evaluation of the substrate activity of C-6 substituted purine ribosides with E. Overexpression of Escherichia coli genes encoding nucleoside phosphorylases in the pET/Bl21(DE3) system yields active recombinant enzymes. Synthesis of 2-chloropurine ribosides with chiral amino acid amides at C6 and their evaluation as A1 adenosine receptor agonists. A Chemo-enzymatic synthesis of β-d-Arabinofuranosyl purine nucleosides. The enzymatic synthesis of antiviral agents. 6-N-substituted derivatives of adenine arabinoside as selective inhibitors of varicella-zoster virus. Nucleosides Nucleotides Nucleic Acids 2018, 37, 20–34. A practical synthesis of xylo- and arabinofuranoside precursors by diastereoselective reduction using Corey-Bakshi-Shibata catalyst. Synthesis of novel 6-substituted amino-9-(β-d-ribofuranosyl)purine analogs and their bioactivities on human epithelial cancer cells. III.1 A simple pathway to a “cis- Nucleoside”, 9-β-D-Arabinofuranosyladenine (Spongoadenosine). Syntheses with partially benzylated sugars. Stereoselective synthesis of 9-β-d-arabianofuranosyl guanine and 2-amino-9-(β-d-arabianofuranosyl)purine. Method of production of 2-chloroadenosine. The preparative method for 2-fluoroadenosine synthesis. Hydrolytic cleavage of N6-substituted adenine derivatives by eukaryotic adenine and adenosine deaminases. direct conversion of 2′-Deoxyinosine to 6-Chloropurine 2′-Deoxyriboside and selected 6-substituted deoxynucleosides and their evaluation as substrates of adenosine deaminase. Adenosine Aminohydrolase: Binding and hydrolysis of 2- and 6-substituted purine ribonucleosides and 9-substituted adenine nucleosides. Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis. Purine nucleoside analogs as immunosuppressive and antineoplastic agents: Mechanism of action and clinical activity. Older and new purine nucleoside analogs for patients with acute leukemias. Purine and 1-deazapurine ribonucleosides and deoxyribonucleosides: Synthesis and biological activity. Treatment of African trypanosomiasis with cordycepin and adenosine deaminase inhibitors in a mouse model. New developments in nucleoside analogues biosynthesis: A review. Synthesis and evaluation of in vitro anticancer activity of some novel isopentenyladenosine derivatives. Synthesis and comparative cytokinin activities of N-(Purin-6-yl)-d- and -l-amino acid methyl esters. Cytokinin Activities of N-(Purin-6-yl) amino Acids, N-(Purin-6-yl) peptides and Related Compounds (A. The synthesis and cytokinin activities of N-(purin-6-yl)amino acids. amino acids with a single reactive amino group1a. The synthesis of N-(6-Purinyl)amino acids. Synthesis of enantiomers of N-(2-aminopurin-6-yl)amino acids. Synthesis and antimycobacterial activity of purine conjugates with (S)-lysine and (S)-ornithine. Synthesis and antimycobacterial activity of N -(2-aminopurin-6-yl) and N -(purin-6-yl) amino acids and dipeptides. Some short-chain N6-substituted adenosine analogs with antitumor properties. Adenosine receptors in colon carcinoma tissues and colon tumoral cell lines: Focus on the A3 adenosine subtype. The A3 adenosine receptor is highly expressed in tumor versus normal cells: Potential target for tumor growth inhibition. John daly lecture: Structure-guided drug design for adenosine and P2Y receptors. A Structure–Activity Relationship Study of Bitopic N 6-Substituted Adenosine Derivatives as Biased Adenosine A 1 Receptor Agonists. The authors declare no conflict of interest.
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